Over and above its pain-relieving effects, conolidine has shown a favorable basic safety margin in preclinical toxicology assessments. Contrary to opioids, which regularly cause respiratory depression at higher doses, conolidine has not made indications of considerable respiratory suppression. In addition, behavioral assessments in murine versions

Plants have already been Traditionally a source of analgesic alkaloids, Whilst their pharmacological characterization is commonly limited. Among this sort of pure analgesic molecules, conolidine, present in the bark with the tropical flowering shrub Tabernaemontana divaricataWhilst this review identifies the correlation amongst conolidine and ACKR3

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